Many of the same tests done on blood and bone marrow samples can also be done on samples taken from your lymph nodes, liver, skin or other body fluids (like the fluid around your spinal cord or lungs) to make a diagnosis.Īnemia occurs when there are too few red blood cells in the body. Some blood disorders may affect other organs directly. Fred Hutch has a team of providers who specialize in doing bone marrow procedures to ensure we collect samples safely and comfortably for any test you need.Īs with your blood, your team may request cytogenetic analysis and genomic testing of your marrow to look for abnormalities in your chromosomes or genes. A pathologist examines and evaluates the cells (using methods like bone marrow smear, flow cytometry and immunohistochemistry). Physicians may use a thin, hollow needle to remove a sample of bone marrow liquid or tissue (bone marrow aspiration or biopsy), typically from your pelvis or breastbone. So tests of your marrow can provide important details about the health of your blood. Stem cells in your bone marrow are responsible for making blood cells. There are many other specific blood disorders that arise in different ways and may have different effects on your body. Other blood disorders have to do with a low level or complete lack of substances the body needs, such as clotting factors in hemophilia, or with the presence of unwanted substances in the blood, such as abnormal proteins in amyloidosis.
For platelets, a low level is called thrombocytopenia.For WBCs, a low level is called leukopenia.For RBCs, a low level is called anemia.In some cases the blood cells don’t form or mature as they should and cannot carry out their normal functions. Some blood disorders - including leukemia, lymphoma, myeloma, myelodysplastic syndrome and myeloproliferative neoplasms - cause unusually low or high levels of blood cells. The disorder and its symptoms depend on precisely what’s gone wrong. Plasma, the liquid part of blood that carries blood cells, nutrients, wastes, hormones and many other substancesĪbnormalities in any of these components or in related cells or tissues can cause a blood disorder.Platelets, which protect against easy bleeding by helping your blood to clot.White blood cells (WBCs), which fight infection.Red blood cells (RBCs), which carry oxygen throughout the body.For these reasons, blood disorders can impact a host of bodily functions. Your body relies on blood to deliver fuel and oxygen to its billions of cells and to combat infections and other diseases. Viruses, Vaccines and Infectious Diseases.Institutional Partners & Collaborations.Vaccine and Infectious Disease Division.
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